alendronate

Adult
Uses
  • osteoporosis prevention or treatment
Contraindications,
drug interactions
or cautions
Contraindications
  • hypersensitivity to alendronate or other bisphosphonates
  • abnormalities of the esophagus (including stricture, achalasia)
  • inability to stand or sit upright for at least 30 minutes
Drug interactions
  • parathyroid hormone, multivitamins/minerals (with vitamin A, D, E, K, folate, or iron)
Cautions
  • use with caution in patients with renal impairment (not recommended for use in patients with CrCl <35 mL/minute)
Adverse Effects
(common and severe)
  • esophagitis
  • hypocalcemia
  • osteonecrosis of the jaw
  • atypical femur fracture
Instructions and dose
(initial; typical)
prevention: 5 mg once daily; treatment: 10 mg once daily
Monitoring
  • bone mineral density should be evaluated 1 to 2 years after initiating therapy
  • assessment of chronic back pain
  • serum calcium and 25(OH)D
Source of Suggestion
Canadian clinical practice guidelines (added on August, 2015)