Uses | • gout |
Contraindications, drug interactions or cautions | Contraindications • severe hypersensitivity reaction to allopurinol • breast-feeding mothers and children Drug interactions • angiotensin-converting-enzyme inhibitors • antiacids Cautions • dose reductions are recommended in patients with renal impairment • allopurinol is of no benefit for acute gout and should generally not be initiated during an acute attack |
Adverse Effects (common and severe) | • skin rash • acute gout attacks • rash • diarrhea • nausea |
Instructions and dose (initial; typical) | 100 mg once daily; usual dosage: 200 to 300 mg/day in mild gout, 400 to 600 mg/day in moderate to severe gout |
Monitoring | • complete blood count • serum uric acid • liver function test • renal function |
Source of Suggestion | WHO Model List of Essential Medicines (Added on August, 2015) |