allopurinol

Uses• gout
Contraindications,
drug interactions
or cautions
Contraindications
• severe hypersensitivity reaction to allopurinol
• breast-feeding mothers and children
Drug interactions
• angiotensin-converting-enzyme inhibitors
• antiacids
Cautions
• dose reductions are recommended in patients with renal impairment
• allopurinol is of no benefit for acute gout and should generally not be initiated during an acute attack
Adverse Effects (common and severe)• skin rash
• acute gout attacks
• rash
• diarrhea
• nausea
Instructions and dose
(initial; typical)
100 mg once daily; usual dosage: 200 to 300 mg/day in mild gout, 400 to 600 mg/day in moderate to severe gout
Monitoring• complete blood count
• serum uric acid
• liver function test
• renal function
Source of Suggestion
WHO Model List of Essential Medicines
(Added on August, 2015)