allopurinol

Adult
Uses
  • gout
Contraindications,
drug interactions
or cautions
Contraindications
  • severe hypersensitivity reaction to allopurinol
  • breast-feeding mothers and children
Drug interactions
  • angiotensin-converting-enzyme inhibitors
  • antiacids
Cautions
  • dose reductions are recommended in patients with renal impairment
  • allopurinol is of no benefit for acute gout and should generally not be initiated during an acute attack
Adverse Effects
(common and severe)
  • skin rash
  • acute gout attacks
  • rash
  • diarrhea
  • nausea
Instructions and dose
(initial; typical)
100 mg once daily; usual dosage: 200 to 300 mg/day in mild gout, 400 to 600 mg/day in moderate to severe gout
Monitoring
  • complete blood count
  • serum uric acid
  • liver function test
  • renal function
Source of Suggestion
WHO Model List of Essential Medicines (Added on August, 2015)