azathioprine

Adult
Uses
  • renal transplantation
  • rheumatoid arthritis
  • Crohn's disease
  • ulcerative colitis
  • dermatomyositis
  • polymyositis
  • immune thrombocytopenia
Contraindications,
drug interactions
or cautions
Contraindications
  • hypersensitivity to azathioprine, pregnancy, patients with rheumatoid arthritis and a history of treatment with alkylating agents (e.g., cyclophosphamide, chlorambucil, melphalan)
Drug interactions
  • angiotensin-converting-enzyme inhibitor, allopurinol, mercaptopurine, natalizumab,rivavirin, sulfamethoxazole, tacrolimus, trimethoprim, warfarin
Cautions
  • patients with rheumatoid arthritis and a history of treatment with alkylating agents (cyclophosphamide, chlorambucil, melphalan) may have a prohibitive risk of malignancy with azathioprine treatment
Adverse Effects
(common and severe)
  • malaise
  • nausea
  • vomiting
  • leukopenia
  • neolasia
  • thrombocytoenia
  • hepatotoxicity
  • increased susceptibility to infection
  • myalgia
  • fever
Instructions and dose
(initial; typical)
indication-specific dosing (usual initial dose for patients with rheumatoid arthritis: 50 to 100 mg once daily)
Monitoring
  • complete blood count
  • total bilirubin
  • liver function tests
  • creatinine clearance
  • thiopurine methyltransferase genotyping or phenotyping
  • symptoms of infection
Source of Suggestion