clozapine
| Uses | • treatment resistant schizophrenia |
| Contraindications, drug interactions or cautions | Contraindications • myeloproliferative disorders, toxic or idiosyncratic agranulocytosis, active liver disease, hepatic failure, severe CNS depression or comatose states, severe renal or cardiac disease, paralytic ileus, uncontrolled epilepsy, previous hypersensitivity |
| Adverse Effects (common and severe) | • drowsiness • dizziness/vertigo • headache • tremor • salivation • sweating • dry mouth • visual disturbances • tachycardia • hypotension • syncope • constipation • nausea • fever |
| Instructions and dose (initial; typical) | 12.5-25mg once daily; 300-450mg once daily |
| Monitoring | • white blood cells |
| Source of Suggestion | Suggestion from clinicians (Added on August, 2015) |