clozapine

Adult
Uses
  • treatment resistant schizophrenia
Contraindications,
drug interactions
or cautions
Contraindications
  • myeloproliferative disorders, toxic or idiosyncratic agranulocytosis, active liver disease, hepatic failure, severe CNS depression or comatose states, severe renal or cardiac disease, paralytic ileus, uncontrolled epilepsy, previous hypersensitivity
Adverse Effects
(common and severe)
  • drowsiness
  • dizziness/vertigo
  • headache
  • tremor
  • salivation
  • sweating
  • dry mouth
  • visual disturbances
  • tachycardia
  • hypotension
  • syncope
  • constipation
  • nausea
  • fever
Instructions and dose
(initial; typical)
12.5-25mg once daily; 300-450mg once daily
Monitoring
  • white blood cells
Source of Suggestion
Suggestion from clinicians (Added on August, 2015)