estradiol

Uses• vasomotor symptoms associated with menopause
• vulvar and vaginal atrophy associated with menopause
Contraindications,
drug interactions
or cautions
Contraindications
• undiagnosed abnormal genital bleeding, current or history of deep vein thrombosis/pulmonary embolism, breast cancer, estrogen-dependent tumor, hepatic impairment, known thrombophilic disorders
Drug interactions
• acetaminophen, anticonvulsants, ascorbic acid, atorvastatin, rifampin, troglitazone, alcohol
Adverse Effects (common and severe)• bloating
• headache
• nausea
• chloasma
• breast tenderness
• breakthrough bleeding/spotting
Instructions and dose
(initial; typical)
oral preparation: 0.5-2 mg once daily, vaginal cream: insert 2 to 4 g daily for 1 to 2 weeks, vaginal tablet: insert 1 tablet (10 mcg) once daily for 2 weeks
Monitoring• monitor for signs of endometrial cancer in female patients with uterus.
Source of Suggestion
Commonly prescribed medication - oral preparation & suggestion from clinicians - intravaginal application
(oral preparation - added on March 2016 - oral preparation & intravaginal application - added on March 2017)