Uses | • vasomotor symptoms associated with menopause • vulvar and vaginal atrophy associated with menopause |
Contraindications, drug interactions or cautions | Contraindications • undiagnosed abnormal genital bleeding, current or history of deep vein thrombosis/pulmonary embolism, breast cancer, estrogen-dependent tumor, hepatic impairment, known thrombophilic disorders Drug interactions • acetaminophen, anticonvulsants, ascorbic acid, atorvastatin, rifampin, troglitazone, alcohol |
Adverse Effects (common and severe) | • bloating • headache • nausea • chloasma • breast tenderness • breakthrough bleeding/spotting |
Instructions and dose (initial; typical) | oral preparation: 0.5-2 mg once daily, vaginal cream: insert 2 to 4 g daily for 1 to 2 weeks, vaginal tablet: insert 1 tablet (10 mcg) once daily for 2 weeks |
Monitoring | • monitor for signs of endometrial cancer in female patients with uterus. |
Source of Suggestion | Commonly prescribed medication - oral preparation & suggestion from clinicians - intravaginal application (oral preparation - added on March 2016 - oral preparation & intravaginal application - added on March 2017) |