• vasomotor symptoms associated with menopause
  • vulvar and vaginal atrophy associated with menopause
drug interactions
or cautions
  • undiagnosed abnormal genital bleeding, current or history of deep vein thrombosis/pulmonary embolism, breast cancer, estrogen-dependent tumor, hepatic impairment, known thrombophilic disorders
Drug interactions
  • acetaminophen, anticonvulsants, ascorbic acid, atorvastatin, rifampin, troglitazone, alcohol
Adverse Effects
(common and severe)
  • bloating
  • headache
  • nausea
  • chloasma
  • breast tenderness
  • breakthrough bleeding/spotting
Instructions and dose
(initial; typical)
oral preparation: 0.5-2 mg once daily, vaginal cream: insert 2 to 4 g daily for 1 to 2 weeks, vaginal tablet: insert 1 tablet (10 mcg) once daily for 2 weeks
  • monitor for signs of endometrial cancer in female patients with uterus.
Source of Suggestion
Commonly prescribed medication - oral preparation & suggestion from clinicians - intravaginal application (oral preparation - added on March 2016 - oral preparation & intravaginal application - added on March 2017)