methotrexate

Adult
Uses
  • psoriasis
  • rheumatoid arthritis
Contraindications,
drug interactions
or cautions
Contraindications
  • pregnancy, blood dyscrasias, liver dysfunction, alcoholism
Drug interactions
  • NSAIDs, phenytoin, sulfonamides, antibiotics
Adverse Effects
(common and severe)
  • bone marrow
  • liver
  • lung
  • kidney toxicities
  • diarrhea
  • ulcerative stomatitis
  • malignant lymphomas
  • tumor lysis syndrome
  • skin reactions
  • opportunistic infections
  • nausea
  • abdominal distress
  • malaise
  • undue fatigue
  • chills
Instructions and dose
(initial; typical)
2.5mg; 7.5mg one time every week
Monitoring
  • complete blood count
  • liver function test
  • renal function test
Source of Suggestion