rivaroxaban
| Uses | • atrial fibrillation • deep vein thrombosis • pulmonary embolism |
| Contraindications, drug interactions or cautions | Contraindications • active bleeding • hepatic disease • pregnancy • breastfeeding • hypersensitivity • severe renal dysfunction (CrCl <30mL/min) Drug Interactions • ketoconazole • itraconazole • posaconazole or ritonavir • concomitant treatment with anticoagulants |
| Adverse Effects (common and severe) | • bleeding and associated complications (weakness/paleness/dizziness/headache/dyspnea/unexplained shock) |
| Instructions and dose (initial; typical) | deep vein thrombosis, pulmonary embolism treatment: 15 mg twice daily |
| Monitoring | • routine monitoring of coagulation tests not required • complete blood count • renal function test prior to initiation |
| Source of Suggestion | WHO Model List of Essential Medicines (Added on August, 2015) |