Uses | • hypertension • heart failure (NYHA class III-IV) • hyperaldosteronism |
Contraindications, drug interactions or cautions | Contraindications • anuria • acute renal insufficiency • significant impairment of renal excretory function Drug Interactions • angiotensin-converting-enzyme inhibitors • atorvastatin • angiotensin II receptor blockers • cyclosporine Cautions • the concurrent use of angiotensin-converting-enzyme inhibitors increases the risk of hyperkalemia |
Adverse Effects (common and severe) | • hyperkalemia |
Instructions and dose (initial; typical) | 25mg; 25-200mg one time a day |
Monitoring | blood pressure, serum electrolytes (potassium and sodium), renal function test, daily weight throughout therapy |
Source of Suggestion | WHO Model List of Essential Medicines (Added on August, 2015) |