tenofovir disoproxil fumarate

Uses• antiviral: HIV-1 infection
Contraindications,
drug interactions
or cautions
Contraindications
• hypersensitivity to tenofovir
Drug Interactions
• adeforvir
• didanosine
• NSAIDs
Adverse Effects (common and severe)• insomnia
• headache
• dizziness
• depression
• pruritis
• skin rash
• nausea
• vomiting
• diarrhea
• abdominal pain
• decreased bone mineral density
• fat redistribution
• immune reconstitution syndrome
• lactic acidosis
• hepatomegaly
• renal toxicity
• pancreatitis
Instructions and dose
(initial; typical)
Adult: 300 mg once daily (in combination with other antiretrovirals)
Monitoring• complete blood counts
• reticulocyte count
• CD4 count
• HIV RNA plasma level
• serum phosphate, serum creatininte
• liver function tests
Source of Suggestion
WHO Model List of Essential Medicines
(Added on August, 2015)