Uses | • antiviral: HIV-1 infection |
Contraindications, drug interactions or cautions | Contraindications • hypersensitivity to tenofovir Drug Interactions • adeforvir • didanosine • NSAIDs |
Adverse Effects (common and severe) | • insomnia • headache • dizziness • depression • pruritis • skin rash • nausea • vomiting • diarrhea • abdominal pain • decreased bone mineral density • fat redistribution • immune reconstitution syndrome • lactic acidosis • hepatomegaly • renal toxicity • pancreatitis |
Instructions and dose (initial; typical) | Adult: 300 mg once daily (in combination with other antiretrovirals) |
Monitoring | • complete blood counts • reticulocyte count • CD4 count • HIV RNA plasma level • serum phosphate, serum creatininte • liver function tests |
Source of Suggestion | WHO Model List of Essential Medicines (Added on August, 2015) |