tenofovir disoproxil fumarate

Adult
Uses
  • antiviral: HIV-1 infection
Contraindications,
drug interactions
or cautions
Contraindications
  • hypersensitivity to tenofovir
Drug interactions
  • adeforvir, didanosine, NSAIDs
Adverse Effects
(common and severe)
  • insomnia
  • headache
  • dizziness
  • depression
  • pruritis
  • skin rash
  • nausea
  • vomiting
  • diarrhea
  • abdominal pain
  • decreased bone mineral density
  • fat redistribution
  • immune reconstitution syndrome
  • lactic acidosis
  • hepatomegaly
  • renal toxicity
  • pancreatitis
Instructions and dose
(initial; typical)
Adult: 300 mg once daily (in combination with other antiretrovirals)
Monitoring
  • complete blood counts
  • reticulocyte count
  • CD4 count
  • HIV RNA plasma level
  • serum phosphate
  • serum creatininte
  • liver function tests
Source of Suggestion