valproic acid

Adult
Uses
  • antiepileptic
Contraindications,
drug interactions
or cautions
Contraindications
  • hepatic dysfunction, urea cycle dysfunction, mitochondrial disorders, children (< 2years)
Drug interactions
  • phenytoin, carbamazepine, phenobarbital, primidone, carbapenem antibiotics, rifampin
Adverse Effects
(common and severe)
  • hepatotoxicity
  • pancreatitis
  • nausea
  • vomiting
  • somnolence
  • dizziness
  • abdominal pain
  • dyspepsia
  • rash
  • diarrhea
  • tremor
  • weight gain
  • back pain
  • alopecia
  • headache
Instructions and dose
(initial; typical)
250mg; 500mg every 8-12 hours; oral liquid: 200mg/5mL
Monitoring
  • complete blood count
  • liver function tests
  • folate
Source of Suggestion