polymyxin b
| Uses | • conjunctivitis (when used with trimethoprim), available on site |
| Contraindications, drug interactions or cautions | Contraindications • hypersensitivity Drug Interactions • ace inhibitors • angiotensin II receptor blockers • antidiabetic agents • lamivudine • methotrexate |
| Adverse Effects (common and severe) | • circumocular rash • burning sensation of eyes • eyelid edema • eye pruritus • eye redness (increased) • lacrimation • stinging of eyes |
| Instructions and dose (initial; typical) | Solution, ophthalmic: trimethoprim 1 mg and polymyxin B sulfate 10,000 units per 1 mL (10 mL). Instill 1 drop in affected eye(s) every 3 hours (maximum: 6 doses per day) for 7-10 days |
| Monitoring | • neurologic symptoms and signs of superinfection • monitor for signs of anaphylaxis during first dose |
| Source of Suggestion | WHO Model List of Essential Medicines (Added on July, 2017) |