Uses | • psoriasis • rheumatoid arthritis |
Contraindications, drug interactions or cautions | Contraindications • pregnancy, blood dyscrasias, liver dysfunction, alcoholism Drug interactions • NSAIDs, phenytoin, sulfonamides, antibiotics |
Adverse Effects (common and severe) | • bone marrow • liver • lung • kidney toxicities • diarrhea • ulcerative stomatitis • malignant lymphomas • tumor lysis syndrome • skin reactions • opportunistic infections • nausea • abdominal distress • malaise • undue fatigue • chills |
Instructions and dose (initial; typical) | 2.5mg; 7.5mg one time every week |
Monitoring | • complete blood count • liver function test • renal function test |
Source of Suggestion | WHO Model List of Essential Medicines (Added on August, 2015) |